Abstract
The synthesis and in vitro characterization of A-119637 and A-123189, two novel, selective and potent alpha1D antagonists, are described.
MeSH terms
-
Adrenergic alpha-1 Receptor Antagonists*
-
Adrenergic alpha-Antagonists / chemical synthesis*
-
Adrenergic alpha-Antagonists / pharmacology
-
Animals
-
Aorta, Thoracic / drug effects
-
Cattle
-
Cloning, Molecular
-
Humans
-
In Vitro Techniques
-
Ligands
-
Male
-
Piperazines / chemical synthesis*
-
Piperazines / pharmacology*
-
Pyrimidines / chemical synthesis*
-
Pyrimidines / pharmacology*
-
Radiopharmaceuticals
-
Rats
-
Spleen / drug effects
-
Vas Deferens / drug effects
Substances
-
A119637
-
A123189
-
Adrenergic alpha-1 Receptor Antagonists
-
Adrenergic alpha-Antagonists
-
Ligands
-
Piperazines
-
Pyrimidines
-
Radiopharmaceuticals